Global trial reveals life saving drug for acute myeloid leukemia

Bone marrow aspirate showing acute myeloid leukemia. Several blasts have Auer rods. Credit: Wikipedia

A landmark paper published today in the New England Journal of Medicine describes the results from a global trial across 148 sites in 23 countries, showing a 30 percent improvement in survival in patients with acute myeloid leukemia (AML).

The Phase 3 clinical trial called QUAZAR, showed that a drug, called CC-486, significantly improved survival in older patients, over the age of 55, with the disease. AML is the most acute blood cancer in adults and its incidence increases with age, with a poor prognosis. With current treatments, the majority of older patients will die of their disease within 2 years of diagnosis.

Around 20,000 people in the United States are diagnosed with AML every year.

The global trial, led by Professor Andrew Wei from Monash University’s Australian Centre for Blood Diseases and a haematologist at Alfred Health, focused on people with AML over 55 years of age, “because of an unmet need to identify new agents able to improve outcome in patients after completing chemotherapy,” he said.

“After intensive chemotherapy, the risk of AML relapse is high. Many older patients are not eligible to receive a and so a less toxic option to reduce disease recurrence is desirable, rather than just being monitored and waiting for the disease to come back,” he said.

“Based on the results of the QUAZAR study, it is very exciting to think that, by taking a tablet that is relatively well-tolerated, we can help reduce relapse risk and improve survival.”

The trial involved 472 patients, with an average age 68 years, who were either given CC-486 or a placebo.

Those receiving the drug—which has the added advantage of being a tablet that can be taken at home—had an average survival from remission of almost 25 months compared to those who did not take the drug, whose average survival was almost 15 months.

Following Professor Wei’s presentation of the results at the American Society for Hematology meeting in the United States in December 2019, the Food and Drug Administration fast-tracked approval for the use of CC-486 in the U.S in September this year.

Professor Wei says the data presented in the NEJM is likely to establish a new standard of care for with AML, “because our findings show that CC-486 significantly delays recurrence of the , thereby prolonging survival and without impacting on quality of life”.

“This is a very significant advance because the drug is easy to administer and means that adults with AML don’t have to spend extra time in hospital,” he said.

Professor Wei added the is currently not approved for use in Australia.


Venetoclax added to standard treatments shows promise in high-risk myeloid blood cancers


More information:
New England Journal of Medicine (2020). DOI: 10.1056/NEJMoa2004444

Provided by
Monash University

Citation:
Global trial reveals life saving drug for acute myeloid leukemia (2020, December 23)
retrieved 23 December 2020
from https://medicalxpress.com/news/2020-12-global-trial-reveals-life-drug.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.





Source link

Health News

mRNA vaccine more effective booster to ChAdOx1 nCoV-19

(HealthDay)—Use of heterologous ChAdOx1 nCoV-19 and mRNA prime-boost vaccination is more effective than homologous ChAdOx1 nCoV-19/ChAdOx1 nCoV-19 prime-boost vaccination, according to a study published online Oct. 17 in The Lancet Regional Health: Europe. Peter Nordström, M.D., Ph.D., from Umeå University in Sweden, and colleagues examined the effectiveness of heterologous prime-boost COVID-19 vaccination among individuals in […]

Read More
Health News

Moving monoclonal antibody treatments for COVID from hospital to home

(HealthDay)—Antibody infusions help keep high-risk COVID-19 patients out of the hospital, but getting the therapy can be a challenge. One U.S. health system has found a creative way to address the problem: home infusions administered by paramedics. They delivered antibody infusions to 144 COVID-19 patients in their homes over three months earlier this year. Most—about […]

Read More
Health News

Most kids newly diagnosed with ADHD aren’t getting best care

(HealthDay)—Preschoolers with attention deficit hyperactivity disorder (ADHD) rarely receive the gold-standard treatment recommended by the American Academy of Pediatrics (AAP) for their condition, a new study reports. The AAP recommends a behavioral therapy technique called “parent training in behavior management,” or PTBM, as first-line treatment for ADHD kids ages 4 and 5. But only 1 […]

Read More