COVID-19 may deepen depression, anxiety, and PTSD among pregnant and postpartum women

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Though childbirth is often anticipated with optimism and enthusiasm, approximately 10 to 20 percent of pregnant individuals also experience mental health challenges during the weeks immediately before and after birth. Depression, anxiety and trauma-related disorders can all be exacerbated by increased stress related to pregnancy and postpartum experiences. But it’s unknown how the stressors of a significant health pandemic can impact these complications. In a new study published in Psychiatry Review, researchers from Brigham and Women’s Hospital surveyed pregnant women and those who had recently given birth, finding concerning rates of depression, generalized anxiety and post-traumatic stress disorder (PTSD) symptoms, which were found to be exacerbated by COVID-19-related grief and health worries.

“We know the is already a time in which women are particularly vulnerable to ,” said corresponding author Cindy Liu, Ph.D., of the Department of Pediatric Newborn Medicine

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Risk for bone fractures up for patients with psoriatic diseases

(HealthDay)—For adults with psoriatic diseases, the likelihood of developing bone fractures is increased, although they have no increased risk for osteoporosis, according to a review published online Nov. 19 in the Journal of Clinical Medicine.

Tai-Li Chen, M.D., from Hualien Tzu Chi Hospital in Taiwan, and colleagues examined bone mineral density (BMD) and the risk for osteoporosis and fractures in patients with psoriatic diseases, including cutaneous psoriasis and , in a systematic review and meta-analysis. Data were included from published observational studies and the random-effect model was used to perform the meta-analysis.

The researchers observed no significant difference between patients with psoriatic disease and nonpsoriatic controls in terms of the standardized mean difference in the absolute value of BMD at the lumbar spine, femoral neck, or total hip. No for osteoporosis was seen in patients with psoriatic disease in the pooled results of the adjusted

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NYC to reopen schools, even as virus spread intensifies

by David B. Caruso and Karen Matthews

West Brooklyn Community High School principal Malik Lewis, left, bumps elbows with former student Jason Cardoso after Cardoso came to pick up the diploma he earned when he graduated in March, Thursday, Nov. 19, 2020, in the Brooklyn borough of New York. Cardoso, along with many West Brooklyn students who graduated in the spring, was unable to get back to the school because he’s working during school hours. The school has been forced to close three times since spring due to coronavirus. (AP Photo/Kathy Willens)

New York City will reopen its school system to in-person learning, and increase the number of days a week many children attend class, even as the coronavirus pandemic intensifies in the city, Mayor Bill de Blasio said Sunday.

The announcement marks a major policy reversal for the nation’s largest , less than two weeks after de

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Vaccine giant to apply for pandemic licence in ‘two weeks’

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The world’s largest vaccine manufacturer by volume said Saturday it would apply for an emergency licence for a coronavirus vaccine within two weeks, and that confusion over the efficacy would not delay its distribution.

Serum Institute of India chief executive Adar Ponnawala also confirmed that the Pune-based giant would be able to produce at least 100 million doses a month from early 2021 of Covishield, which was developed by Astrazeneca and Oxford University.

Poonawalla spoke after a visit to the plant by Prime Minister Narendra Modi, whose government wants 300-400 million doses by July next year as the country battles a new surge in the pandemic.

India, the second worst hit country after the United States, is expected to pass 10 million cases in early December.

AstraZeneca has said further research was needed on the vaccine after scientists raised confusion about Covishield’s efficacy.

It revealed that

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Ireland eases Covid-19 lockdown restrictions ahead of Christmas

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Ireland on Friday announced a staggered easing of coronavirus lockdown restrictions to allow some businesses to reopen and for families to gather ahead of Christmas.

Speaking in a televised address, Taoiseach Micheal Martin said the upcoming festive period “cannot and will not be the kind of Christmas we are used to” but added the easing of restrictions would offer “some respite from the hardships of 2020 and in particular, the last six weeks”.

“In easing restrictions we are going as far as we believe it is possible to achieve the best balance of health, economic, and social considerations, but no further,” he said.

“The encouraging news is that the efforts and the sacrifices that each of us has made is working. Lives have been saved,” he added.

According to measures agreed by the Irish government, all , museums, galleries and libraries will be allowed

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Big data powers design of ‘smart’ cell therapies for cancer

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Finding medicines that can kill cancer cells while leaving normal tissue unscathed is a Holy Grail of oncology research. In two new papers, scientists at UC San Francisco and Princeton University present complementary strategies to crack this problem with “smart” cell therapies—living medicines that remain inert unless triggered by combinations of proteins that only ever appear together in cancer cells.

Biological aspects of this general approach have been explored for several years in the laboratory of Wendell Lim, Ph.D., and colleagues in the UCSF Cell Design Initiative and National Cancer Institute- sponsored Center for Synthetic Immunology. But the new work adds a powerful new dimension to this work by combining cutting-edge therapeutic cell engineering with advanced computational methods.

For one paper, published September 23, 2020 in Cell Systems, members of Lim’s lab joined forces with the research group of computer scientist Olga G. Troyanskaya, Ph.D.,

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